 496  170. Another striking and rather frequent exception from the criteria characterizing cancers is represented by basalcell carcinomas of the skin, which may develop following an occupational or environmental exposure to sunlight, coal tar, and arsenicals. Basal-cell cancers of the skin do not produce metastases and thereby lack one of the most important properties of malignant growths. 171. Our experience suggests that the presence of a bruit is strong evidence of a partially open but stenosed internal carotid artery; and subsequent arteriograms usually support this opinion. The absence of a bruit, despite transient episodes or a persistent neurologic defect, suggests most frequently a complete occlusion. Again, this has been supported by arteriography. 172. Evidence of the altered responsiveness persisted throughout a period in which spontaneous paroxysmal activity was abolished and self-re-excitation, to judge by the unit record, was absent. By excluding reverberating impulses as the basis for the long lasting change in cellular behavior the isolation experiment made it necessary to search for structural alterations. 173. These findings indicate that glucose is incorporated into glycogen as an intact unit - i.e., with little or no cleavage of the carbon chain. This view on the mechanism of the conversion of glucose to liver glycogen is fully borne out by our demonstration of Identical recoveries of C14 in glycogen when liver slices were incubated with glucose-1-C14, -6-C14, and -E-C14. 174. In the present article we report the results obtained by using ferritinas a tracer to investigate glome-rular permeability in rats with proteinuria induced by PA treatment. The findings confirm the conclusions drawn and support the assumptions formulated in our previous paper. In addition, they provide new information about certain morphological and physiological aspects of the nephrotic syndrome. 175. Proceeding on the premise that the opalescence produced in serum by streptococcal extracts migth be due to low density lipids or lipid-protein complexes liberated from their normal associations with serum lipoproteins, an experiment was undertaken to determine whether such products could be separated from extract-treated sera by ultracentrifugal flotation at normal serum density. 176. These facets of the vasomotor transfer of heat have been 496 |
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